The Effects of Varicocele on DNA Morphology

نویسندگان

  • Ozkan Bagci
  • Ali Murat Gokce
  • Mustafa Gunes
چکیده

Varicocele is one of the major causes of infertility in men. Although there are different theories related to the pathophysiology of the varicocele, the exact pathophysiologic mechanism remains unknown. Sperm DNA damage may be the cause of undiagnosed infertility problems. The standard semen examination may not be sufficient to determine the etiology of infertility. For this reason, extra tests are needed to identify sperm DNA damage. Despite conflicting reports, many studies have shown that varicocele repair improves the quality of sperm DNA.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P-13: Evaluation of Sperm Acrosin Activity and Chromatin Structure in Varicocele Patients Before and after Varicocelectomy

Background: Evaluation and comparison of total acrosin activity along with DNA integrity in the semen samples obtained from the varicocele individuals before and after the surgery and also in fertile individuals. Materials and Methods: Semen parameters, protamine deficiency, DNA fragmentation and Total acrosin activity were measured in patients with a clinical diagnosed varicocele of grade II o...

متن کامل

Can Altered Expression of HSPA2 in Varicocele Patients Lead to Abnormal Spermatogenesis?

Background Heat shock protein A2 (HSPA2) is correlated with sperm maturity and function. Therefore, dysfunctional expression of this gene results in abnormal spermatogenesis. On the other hand, DNA damage in spermatozoa is considered to be an important cause of male infertility, and the presence of sperm with DNA fragmentation and chromatin abnormalities in human ejaculates is well documented, ...

متن کامل

P-72: Effect of Subinguinal Varicocelectomy on Human Sperm DNA Integrity and Semen Parameters

Background: Varicocele occurs in approximately 15% to 20% of the male population and it is the most common cause of poor semen parameters. It has been demonstrated that patients with varicocele have poor chromatin packing, DNA damage and nuclear anomalies than the healthy men. Therefore, the aim of this study was to evaluate sperm chromatin integrity and semen parameters in these patients after...

متن کامل

P-47: Comparison of Sperm Acrosin Activity and DNA Fragmentation between Varicocele and Infertile Individuals

Background: Introduction assessment of sperm functional tests along with routine semen analysis may provide further information in the etiology of varicocele in different subpopulations. Therefore, in this study, in addition to assessment of sperm chromatin integrity, we aimed to assess the total acrosin activity which has proven to have major role during in vitro and natural fertilization in v...

متن کامل

P-13: Comparison of Sperm Quality, Oxidative Stress, DNA Fragmentation, Protamine Deficiency, and DNA Methylation in Varicocele and Fertile Individuals

s:1993:"Background: There are many approaches that gene expression is controlled in eukaryotes. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression and lock genes in the "off" position. In addition, sperm DNA damage can correlate with DNA methylation defect. There is evidence that sperm of infertile men contain more DNA damage than fertile men and t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014